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It was found out that naltrexone and bupropion combined, that could be marketed in the future as Contrave, provide better weight loss results than dieting and exercise alone.

Using two separate drugs to lose weight can be very effective you can find combinations before the FDA now awaiting approval. When dealing with fat loss and the those who go through it one should err along the side of caution and allow the FDA do its job and demand some investigation be done so the public is aware of the side effects and perils associated with the medications before we drive them. Keep in mind that drug companies will be in business to generate money and that they would say anything to keep people on their medications.

Researchers discovered that participants investing in this drug to get a year, dropped excess weight within four weeks and have kept the body weight off through the entire 56 weeks with the study. Contrave is really a combination in the drugs naltrexone and bupropion, which seems to reflect a new trend of weight-loss drugs which are made up of multiple active ingredient, which may make them more effective and safer.

Combo-pilling will be the newest fad or even better the newest in the future under scrutiny and for that reason it is just more publicly known in recent months, comb-pilling to lose weight has been around since the eighties. The biggest reason that by using a combination of pills is now popular is the fact that since right now there are no long term prescription weight loss supplements that have been approved by the FDA apart from orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications however some of the combinations are actually rejected or have yet to be approved by the FDA.

Seizures are a side effect with Contrave and shouldn't be taken in people who have seizure disorders. The drug may also raise blood pressure and heart rate, and really should not be used in individuals with a history of cardiac arrest or stroke in the previous six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy using the drug.

The FDA also warned that Contrave can raise blood pressure and pulse rate and must stop used in patients with uncontrolled high blood pressure level, along with by anyone with heart-related and cerebrovascular (circulation system dysfunction impacting mental performance) disease. Patients which has a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes having a boxed warning to alert health care professionals and patients towards the increased probability of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for quitting smoking.


"This will be the first drug I'm mindful of that targets the appetite and reward centres within the brain," he explained.